Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenic
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چکیده
منابع مشابه
Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenic.
Mutations in genes that encode components of the phosphatidyl-inositol 3-kinase (PI3-kinase) signaling pathway are common in human cancer. The recent discovery of nonrandom somatic mutations in the PIK3CA gene of many human tumors suggests an oncogenic role for the mutated enzyme. We have determined the growth-regulatory and signaling properties of the three most frequently observed PI3-kinase ...
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Mutations in genes functioning in different pathways frequently occur together in the same cancer, whereas mutations in the same pathway tend to be mutually exclusive. However, the majority of colon, breast, and endometrial cancers that possess mutations in PIK3CA, the catalytic subunit p110alpha of phosphatidylinositol 3'-kinase (PI3K), also possess mutations or alterations in genes upstream o...
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Phosphatidylinositol-3 phosphate kinase (PI3K) and phosphatase protein homologue to tensin (PTEN) are involved in cell signaling by catalyzing opposite reactions in the balance of phosphatidylinositol-3,4,5,-trisphosphate and are deregulated in many tumors. Recently, Saal et al. (1) reported that these two proteins are altered in a consistent fraction of breast cancers and, more importantly, th...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2005
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.0408864102